Crush Ringtone

The Crush Ringtone by David Archuleta has quickly become one of the most popular ringtones in the world. It has peaked at # 1 on several popular mobile charts and is currently # 2 on the US iTunes Top Songs Chart. Based on its popularity, the ringtone might soon become one of the most popular mobile phone ringtones ever released!

Crush is the debut single by David Archuleta, American Idol seventh season runner-up. The track was written by Jess Cates, Dave Hodges, and Emanuel Kiriakou. A digital download of the song became available on August 12, 2008. After just one day of airplay, Crush was able to debut at # 93 on the Billboard Pop 100 and # 57 on Pop 100 Airplay. The song is also currently one of the most tracks at Mainstream CHR radio stations.Following the song's digital release onto the US iTunes store on August 12, 2008, the song rose to the # 1 spot on iTunes in less than 24 hours. Crush debuted on the Canadian iTunes store at # 2 and is expected to debut on the Billboard Hot 100 next week.

The popularity of the song has helped make it such a popular phone ringtone. The track has also topped Canadian and Australian music charts, making the ringtone very popular in those nations as well as in the United States.

There is no doubt that David Archuleta's incredible new hit single will end up being one of the most popular ringtones of 2008. If you're looking for a hot new ringtone for your mobile phone – the Crush Ringtone is an awesome choice!

Work and Study

The relationship between work and study should not be underestimated.

It is important that youngsters in general, and teenagers in particular, get real life experience of what it takes to succeed in the ‘real world’, what it takes to make money, and how hard dad or mum have to work to earn those extra few cents.

Recently a dad talked about the problems of getting his son to study; the family is wealthy and the son saw little need to make any effort to revise, do well in his forthcoming exams, and move onto a university and undergraduate subject with prospects of a rewarding career.

He saw his parents, particularly mum, as a ‘soft touch’.

The harder the concerned parents tried, the more obstinate the son became; the inverse law of proportionality seemed to be at work, or perhaps the law of diminishing returns. Necessity was definitely not the mother of invention!

‘Man he is a Lazy B…!’ complained the father.

At school, the youngster seemed to have learnt a lot about his ‘rights’ – but little about responsibility.

He didn’t realise that ‘rights’ and ‘responsibilities’ are the same bedfellows – they both start with the letter ‘r’!

The current situation was inevitable…

Things changed, however, after our recommendation that the son spend time working in the kitchens of one his father’s famous restaurants over the summer holidays (well, what else did he expect given his parents’ gentler efforts?).

Washing plates to earn his pocket-money was no fun; it didn’t take long before the grades started to improve.

Study was clearly a better option than washing plates in the kitchen.

Take Warren Buffet, one of the richest men in the world.

Warren has a wise head on his shoulders and drives the same old car and lives in the same old house as he did at the start of his career; his common sense has to be respected since his actions reflect his words.

He can afford to live in mansions, drive better cars but through his example has made clear that he intends to give most of his wealth to charity.

Warren believes that his children must learn to earn a living, make their own way in the real world.

The last thing he wants is to ‘handicap’ his progeny by handing over his billions.

Some of the smartest students at The University of Oxford in The Business Management School often spent their summer holidays waiting at tables before they got First Class Honours.

They are now CEOs of major companies, earning a very healthy living.

Consider another example from the world of tennis, the William sisters where Venus and Serena dominated the women’s game for many years.

Their early history is one of being introduced to the ‘Bronx’ by their dad where gang bullets were not uncommon whilst they trained.

The William sisters soon realized that working for success in tennis was a better option than living in ghettos.

Where cajoling fails, direct experience often succeeds.

If you want your children to study more effectively, let them work for it!

Best Tips on Group Health Insurance

Perhaps many of you are wondering what a group health insurance policy really means. Well, the answer is not complicated at all! It is just an insurance coverage made by an employer or other authority that is meant to cover all individuals in a particular group!

A group health insurance gives an employer the advantage of not paying the whole premium for the insurance policy in order to cover his employees. In the past, an employer was expected to pay for all the benefits of the employees, but fortunately, now the times have changed and an employer only has to donate just a part of the health insurance premium of the employees.

The general attitude of the insurance companies is to offer lower rates for a group health insurance than on an individual one. This is the main reason why people who are self employed to be aiming for a small business health insurance too. These persons can not be blamed, even if they incorporated to give the insurance company the impression of a larger corporation, as they are only trying to get a good deal on their small business health insurance rates. The result is that each and every person struggles to get an insurance plan, as a small business health insurance is very cheap when compared to individual health insurance.

It is a commonly known fact that group health insurance plans are very much appreciated by all the employees. This is the main reason why most employees value it very much too. A group health insurance policy or a small business health insurance has contributed to the success of many organizations. They have that enabled them to continue employ new people and, at the same time, keep the best people in their business!

No matter what group health insurance plans, service suppliers or a health maintenance plans that a company may offer, there are so many places where you can get informed about these things. You must carefully analyze the group health insurance quotes that a number of insurance companies offer, before deciding if there is something to suit your expectations.

In order to make the best decision regarding a group health insurance, a recruiter must study all the websites and brochures of the health insurance companies that the employee has selected and intends to engage. After comparing their service plans, costs and methods of payment, you must also keep an eye on the starting and ending dates of the insurance policies. The interesting, but disturbing thing is that some health insurance companies only cover you from your third payment, therefore you must be very well informed before making such an important decision.

Last, but not least, there is one more thing you'll have to consider before choosing a group health insurance plan or a small business health insurance: there should be any services or illnesses that are excluded from the policy, it is best to know it from the start. This is the main reason why it is for the best interest of any employee to keep away from any group health insurance policy that only covers a small number of diseases.

Preformulation and Formulation Development

Optimizing Conformational Stability and Biological ActivityMaintenance of the native three dimensional conformation is critical for the long term stability and biological activity of biotherapeutics. Biophysical characterization techniques such as circular dichroism, differential scanning calorimetry, FTIR, dynamic light scattering, and fluorescence spectroscopy provide a mechanism to assess the conformational and thermodynamic stability of proteins under a range of formulation conditions. These tools allow development scientists to differentiate various various buffer, pH, ionic strength, and excipient conditions, and identify the conditions that confer the optimum environment for the therapeutic protein.

Utilizing Advanced Statistical Design for Preformulation Development Preformulation development includes statistical design of experiments, allowing simultaneous evaluation of multiple factors and evaluation of interactions between factors. It is crucial to use advanced biophysical characterization techniques to evaluate the conformational stability of large molecules in addition to traditional methods for evaluation of chemical stability.

A large molecule preformulation development program typically includes the following activities:
Evaluate the effect of pH, buffer type, and ionic strength on solubility.
Evaluate the effect of various excipients on improving solubility if necessary.
Evaluate effects of pH, buffer type, and excipients on conformational stability.
Evaluate the effect of pH, buffers, excipients and ionic strength on physical and chemical stability.
Utilize a statistical design approach to identify the optimal conditions for structural, physical and chemical stability.
Perform forced degradation to elucidate product degradation pathways and to demonstrate the stability-indicating capacity of the analytical methods.
Forced degradation studies typically include restricted oxidation, deamidation, aggregation (via agitation), and / or acid / base hydrolysis.
Evaluation of heat stress, photo stress, and freeze thaw are also performed.

Looking for information on Analytical Development and other related resources?

Formulation Development for Numerous Dosage FormsFormulation development includes dosage forms for parenteral, oral topical and inhalation administration, including liquids, gels, suspensions, emulsions and lyophilized powders. Formulation scientists are highly skilled in the development of the dosage forms most relevant to biotherapeutics, with particular expertise in lyophilization and development of stable liquid formulations for proteins. High concentration antibody formulation development for subcutaneous administration requires particular emphasis on viscosity and tonicity. Lyophilization cycle development is performed in the context of the unique thermodynamic properties of the API to deliver an efficient, scalable, transferable process resulting in optimum product stability and reconfiguration characteristics. Formulation development capabilities also include:

Effect of excipients on solubility, tonicity, and viscosity Evaluation of antioxidant and conservative compatibility Container-closure compatibility Long term and accelerated stability studies.

Advantages of Formulation Development Approach. This outlined approach to preformulation and formulation development result in significant savings to the client by eliminating the variables associated with suboptimal formulations. Preclinical development efforts in PK, PD, ADME and toxicology occur with confidence that additional uncontrollable variables from unstable formulations are not introduced into the study. This benefit extends far into clinical trials as well, where assessment of toxicity, dosage levels and efficiency are substantially influenced by an optimal formulation that preserves the three dimensional conformation of the therapeutic protein. By eliminating uncontrolled stability variables, the focus is placed solely on the therapeutic performance and clinical outcome.